Ryan Hoiland

My research interests center on improving outcomes for patients that have suffered an acute central nervous system (CNS) injury, such as a hypoxic ischemic brain injury, traumatic brain injury, or traumatic spinal cord injury. These acute CNS injuries have dismal outcomes and currently lack efficacious therapies. The specific foci of my research are: 1) determining the mechanisms that impair the restoration of oxygen delivery and utilization within the CNS following an acute injury; 2) characterizing the role of neuroinflammation as a determinant of acute CNS injury severity; 3) Illuminating new therapeutic targets for the treatment of acute CNS injuries. Across these foci I employ several experimental paradigms including disease models (e.g., rodents), healthy human studies, and clinical studies. Separate to this work, I hold experience and interest in the mechanisms that regulate cerebrovascular function in humans, cerebrovascular health across the lifespan, and interventions/strategies to sustain or improve cerebrovascular function.