Microglia are the primary immune cell of the brain, but have roles outside of immunity as well as being implicated in the pathogenesis of many CNS disorders. Here I will show how we can use CSF1R inhibitors to control the microglial population in vivo, and elucidate their functions in both the homeostatic and disease brains. I will focus on the involvement of microglia in Alzheimer’s disease, and also detail several new genetic models to understand the disease progression.
Zoom option if unable to attend in person