In 1973 John Heuser and Tom Reese demonstrated that neurotransmitter was released from neurons via the fusion of neurotransmitter-filled vesicles with the cell membrane. But at the same time, these […]
Dopamine is a neuromodulator that codes information on various time scales. I will discuss recent progress on the identification of fast release mechanisms for dopamine in the mouse striatum. I will present data […]
Mammals use a sophisticated, multi-regional memory system to guide behavior. A major goal of neuroscience is to understand the mechanisms—ranging from molecular to cellular to systems—that make this possible. Spruston […]
The Heller Lab research program is focused on discovering molecular mechanisms by which epigenetic reprogramming contributes to neuropsychiatric disease. To this end, Dr. Heller pioneered the use of targeted epigenetic […]
Brain function is largely shaped by experience in early life, creating windows of both great opportunity and vulnerability. Our work has focused on the biological basis for such critical periods, […]
Metabolic MRI allows observing energy metabolism, neurotransmission, second messaging, endocrine signaling, antioxidants, protein metabolism and dynamic membrane processes in the human brain. Related quantitative metabolic imaging biomarkers are beneficial for […]
Microglia are the primary immune cell of the brain, but have roles outside of immunity as well as being implicated in the pathogenesis of many CNS disorders. Here I will […]
Zoom option if unable to attend in person Zoom link here (click on “Join a meeting”) Meeting ID: 99412 188589 Passcode: 188589 Over the past 25 years the costs of drug development […]
For decades, neuroscience has focused almost exclusively on stereotyped, reductionist, and over-trained behaviors due to their ease of study. In contrast, naturalistic behavior provides a rich diversity of movements, but this feature […]
Zoom option if unable to attend in person Zoom link here (click on “Join a meeting”) Meeting ID: 99412 188589 Passcode: 188589 The CNS is an immune-privileged organ, yet we know that […]
Zoom option if unable to attend in person Zoom link here (click on “Join a meeting”) Meeting ID: 99412 188589 Passcode: 188589 The study of how the brain regulates learned fear has […]
Maternal cannabis use is a growing public health concern, yet the long-term effects of prenatal cannabis exposure remain elusive. Our understanding of how prenatal cannabis exposure affects the brain and […]
The Neuroscience Research Colloquium (NRC), is a series of lectures featuring local and international neuroscientists.
